MTP 131 acetate

CAS No. 1334953-95-5

MTP 131 acetate ( Elamipretide Acetate )

Catalog No. M28051 CAS No. 1334953-95-5

MTP 131 (acetate) is a small mitochondrially-targeted tetrapeptide.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 88 Get Quote
5MG 120 Get Quote
10MG 192 Get Quote
25MG 338 Get Quote
50MG 501 Get Quote
100MG 705 Get Quote
500MG 1494 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    MTP 131 acetate
  • Note
    Research use only, not for human use.
  • Brief Description
    MTP 131 (acetate) is a small mitochondrially-targeted tetrapeptide.
  • Description
    MTP 131 (acetate) is a small mitochondrially-targeted tetrapeptide.(In Vitro):Pretreatment of cells with MTP 131 (acetate) inhibited H2O2?induced cytotoxicity and reduced LDH release in a dose?dependent manner, compared with cells treated with H2O2 alone. Mitochondrial depolarization and ROS generation were also prevented by MTP 131 (acetate) pretreatment. In addition, MTP 131 (acetate) pretreatment inhibited cytochrome c release from mitochondria to cytoplasm, and significantly reduced apoptosis in RGC?5 cells, compared with cells treated with H2O2 alone.(In Vivo):18-week-old db/db mice have reduced renal and cardiac superoxide levels, as measured by dihydroethidium oxidation, and increased levels of albuminuria, mesangial matrix accumulation, and urinary H2O2 Administration of MTP 131 (acetate) significantly inhibited increases in albuminuria, urinary H2O2, and mesangial matrix accumulation in db/db mice and fully preserved levels of renal superoxide production in these mice. MTP 131 (acetate) also reduced total renal lysocardiolipin and major lysocardiolipin subspecies and preserved lysocardiolipin acyltransferase 1 expression in db/db mice.
  • Synonyms
    Elamipretide Acetate
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1334953-95-5
  • Formula Weight
    639.8
  • Molecular Formula
    C32H49N9O5?XC2H4O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C=C(C=C1C)O)=C1C[C@H](NC([C@H](N)CCCNC(N)=N)=O)C(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CC2=CC=CC=C2)=O)=O.CC(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Polishchuk PG, et al. Application of random forest approach to QSAR prediction of aquatic toxicity. J Chem Inf Model. 2009 Nov;49(11):2481-8.
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